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2019;8:e45572
Some people experience minimal discomfort, while others report weeks of persistent nausea that requires active management strategies to tolerate treatment
Funding This work was funded by grants from the NC3Rs (NC/M001083/1) (MW), Diabetes UK (BDA 13/0004785), Diabetes Research and Wellness (SCA/OF/12/13), The Lollipop Foundation (MW and AR), the Leverhulme Trust (DBG3000) (KB), the BBSRC (BB/M00015X/2) (GL), Karolinska Institutets strategic research program in diabetes (MFT), The Novo Nordisk Foundation (DH), Barndiabetesfonden (DH) and pump priming funding from the Cambridge University Isaac Newton trust
In addition, proinflammatory nonesterified free fatty acids generated from the esterification of chylomicron triglycerides may lead to the release of inflammatory mediators and free radicals, further contributing to pancreatic damage
Its also important to note that some drugs can affect the absorption of cobalamin, including neomycin, potassium chloride, para-aminosalicylic acid, and colchicine
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